Osteosarcoma

The most common primary bone tumor affecting children and young adults. Boys between ages 13 and 16 years are at higher risk. In children, the tumor occurs most frequently at the metaphyses of long bones such as the distal femur, proximal tibia and proximal humerus
Constitutional symptoms such as fever, weight loss, and malaise are usually absent. On physical examination, the most important finding is a tender soft-tissue mass. Characteristics x-ray findings include a spiculated ''sunburst'' pattern and periosteal elevation known as Codman triangle.
Alkaline phosphatase and lactate dehydrogenase are elevated from turnover of damaged osteocytes; high levels may correlate with adverse prognosis. Increased ESR rate is a non-specific marker of inflammation.

Treatment :

includes tumor excision and chemotherapy